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The repertoire of naturally occurring proteins is limited and many molecules induce multiple conflicting effects. Our group aims to redesign existing proteins and engineer new proteins that overcome these limitations. Combining cutting-edge technologies from molecular engineering, structural biophysics, and translational immunology, we create new platforms for the development of targeted therapeutics to treat a broad range of immune diseases.


Congratulations to Seth, Pao, and Ben on their article in Cell ChemBio!


Check out our latest projects in molecular immunoengineering!


Learn more about the research

team in the Spangler group!


© 2023 by Spangler Lab. Image credit: Matthew Blake Kelley.

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