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We are particularly interested in engineering antibodies to bias immune activity for applications in immunological disorders such as cancer and diabetes. For over 20 years, antibodies have served as the most powerful tool in immunotherapy, acting through a range of mechanisms including target protein inhibition, immune cell recruitment, delivery of cytotoxic moieties, and modulation of host response. However, antibody efficacy is hampered by acquired resistance and target mutation, necessitating the development of new molecules that act through complementary mechanisms. Building on biophysical insights and new engineering platforms developed in our group, we discover, deliver, and preclinically evaluate antibodies that recruit novel mechanisms to target immune diseases.
© 2022 by Spangler Lab. Image credit: Matthew Blake Kelley.