The repertoire of naturally occurring proteins is limited and many molecules induce multiple conflicting effects. Our group aims to redesign existing proteins and engineer new proteins that overcome these limitations. Combining cutting-edge technologies from structural biophysics, molecular engineering, and translational immunology, we create new platforms for the development of targeted therapeutics to treat a broad range of immune diseases.
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team in the Spangler group
© 2020 by Spangler Lab. Image credit: Matthew Blake Kelley.